The Roxborough store, owned by the Roma family, won with 64 percent of the vote. Sweet Elizabeth's Cakes also had a strong showing.
Commenters displayed their support for Cafe Roma's with much enthusiasm.
"Cafe Roma by far has the best cupcakes! Fresh and all made from scratch 'old school bakery.' I love their red velvet, it's the best!" Johnny 5 said.
Angela Sposato called it the "best kept secret in Philadelphia."
Debbie Thomas showed love for the runner up, too:
"I love the cupcakes at Cafe Roma. In fact everything else I've had there so far has been great too! I am going to have to try Sweet Elizabeth's cupcakes. They came in 2nd and that's pretty good considering they haven't been on Main Street that long."
Check back Monday for this week's poll, the best place to buy flowers.